Welcome to the Population Genomics Laboratory of the Institute of Genetics and Biophysics of the National Research Council. We are interested in understanding causes and consequences of genetic diversity and how natural selection in humans affects loci related to diseases.

"Fascinating" (Lieutenant Spock)

400

Research

GReP - Genomics of Recurrent Pregnancy Loss

Approximately 70% of all human fertilizations are naturally aborted, with most occurring before the mother knows she is pregnant. Miscarriages that occur later in pregnancy are often due to non-viable genetic variation and this is very likely in the case of Recurrent Pregnancy Losses (RPL).

Numerical and structural chromosomal abnormalities are routinely investigated to understand causes of RPL, while the study of small-size sequence variants that can impact gene function has been neglected, leaving a whole range of possible causes unexplored.

With this project we want to identify variants severely disrupting genes and regulatory functions, therefore incompatible with life, using whole genome sequence of DNA extracted from chorionic villi of miscarriages collected from women with RPL.

Our medRxiv preprint on this project can be find here

GReP code is shared here git

preSeq_screening
We are interested in sequencing euploid embryos from miscarriages, therefore we do a pre-sequencing screening to exclude aneuploidies and comorbidities. Euploid embryos are sequenced and sequences are used to identify mutations. We expect that highly deleterious dominant mutations as well as rare moderately to highly deleterious recessive mutations contribute to miscarriage. Participant inclusion criteria (e.g. recurrence, consanguinity, selection of comorbidities) will ensure the prevalence of genetic over environmental causes.

Collaborations

Funding

loghi_grep

vgpop - Population genetics from variation graphs

Variation graphs are a pangenomic model based on a compact representation of the mutual alignment of many genomes. They are used to compress information from vast sequence sets and support the explicit representation of both simple and complex genomic variants.

GRaphchrX
A graph is made up of vertices which are connected by edges. It can represent alignment and variation among sequences. This graph shows an A/T single nucleotide polymorphisms. The path below with red peppers shows on of teh two possible paths through the graph.

We are intersted in developing methods to compute population genetic statistics directly from variation graphs. Such approaches will allow us to explore complex genomic variants which are often excluded from most of the existing population genetic methods. As our first goal we would like to adapt existing code for population genetic analyses to variation graphs, and in the future we would like to explore new methods to answer basic population genetic questions based on information contained in complex genetic variants.

vgpop code is shared here git

Collaborations


HD-DittoGraph - a digital human Embryonic Stem Cell platform for Hungtinton’s repeats

This project aims to identify the genetic factors that are implicated in instability of the CAG repeats in the Hungtinton’s gene HTT, both during mitotic cell replication and in post-mitotic neurons. We use a human embryonic stem (hES) cellC-based cell platform, barcoded DNA libraries, CRISPR technologies and long-read third generation DNA sequencing.

preSeq_screening

CAG sizing using STRIque on Nanopore sequencing data obtained from libraries generated starting from a donor plasmid carrying the sequence [CAG]48-CAA-CAG. Several combinations of parameters (prefix/suffix size, Qscore, lenght of the reference sequence) were used. Accurate CAG size was detected under most of the combinations used.

Collaborations


SARS-CoV-2 - Genomics of COVID19

With the emerging of the COVID19+ pandemic we feel motivated to give our contribution as geneticists. Among the many aspects worth working on, we chose to deal with the paucity of SARS-CoV-2 genomic sequences from Italy publicly available.

wolrd_covid19
Despite Italy being one of the earliest countries hit by the pandemic, as we write (04/05/20) there are only seven sequences from samples collected in Italy in GenBank.

We are committed to collect, sequence and openly publish as many samples as we can. Knowledge of the SARS-CoV-2 genomic sequence will enable basic research on COVID19, including monitoring the pandemic diffusion, improving genetic testing and develop effective vaccines.

These consideration were presented at the Commissione sanità of the Italian Senate of the Republic in May 2020. Slides can be find here

We are working on SARS-CoV-2 genomics along two research lines:

  1. In collaboration with CEINGE we are sequencing SARS-CoV-2 genomes using third-generation sequencing.

  2. We are part of a network that aim to develop a platform for sharing and analyzing genomic sequence information from samples collected in the Region Campania in Italy. This research is supported by Regione Campania – Recover – Covid 19 -DPGR n. 45 (06/03/2020). Prot. 2020, 0213629 del 05/05/2020.


PARDOM - Domestications of Phaseolus

Phaseolus is a unique example of multiple parallel domestication events that provide a natural experiment to study convergent phenotypic evolution associated with convergent genomic and/or transcriptomic changes. With the project PARDOM (Parallel Domestications: the Phaseolus replicated experiment to understand genome evolution and adaptation), we want to study convergent evolution in four replicates of the domestication process in P. vulgaris (PV) and P. lunatus (PL), two highly collinear species each domesticated independently in Mesoamerica and the Andes, resulting in at least four independent domestication events.

This project is in collaboration with: - Roberto Papa

PARDOM is funded by PRIN 2017 20177RL4KL

People

Vincenza Colonna

I am a researcher at the Institue of Genetics and Biophysics of the Italian National Research Council. I graduated in Evolutionary Biology from University of Napoli Federico II (Italy), did postdoctoral work at University of Ferrara (Italy) and at the Wellcome Trust Sanger Institute (UK). I was lectures in Genetics and Bioinformatics at the University of Ferrara (Italy).

vcolonna

+ See my full C.V. here.

I am a population geneticist and an expert in bioinformatics, working mainly with human data.

I led research projects on: analysis of genomic sequences (assembly, variant calling) and genomic inference (functional interpretation of genetic variants);population genetic analyses for inference on demography and natural selection; genetics of isolated populations; evolutionary medicine; genetics of rare genomic variants.

I have actively collaborated on projects involving RNAseq data analysis and general statistical inference. During my undergraduate training, I worked on projects on molecular biology.

I am an experienced trainer in teaching basic lab skills for research computing (e.g. programming languages, version control, statistical analyses).

I founded and led OBiLab, a project on training in Bioinformatics


Silvia Buonaiuto, PhD student

silvia I am a Phd Student at National Research Council and Università della Campania Luigi Vanvitelli. I work on a project that studies idiopathic recurrent miscarriage and aims at identifying genetic variants likely to cause miscarriages to ultimately improve prenatal diagnosis.

I have a master’s degree in Biology from the University of Napoli Federico II. I did a master thesis in molecular biology at the Department of Biology.


Gianluca Damaggio, PhD Student

gianluca I received a bachelor’s degree in Molecular Biology and a master’s degree in Biology at the University of Napoli Federico II (Italy), my past research was based on the analysis of embryonic whole-genome sequences from recurrent miscarriages in humans. My interest is to investigate the enrichment of deleterious consequences in our cases compared to a control population.

Currently, I am a PhD student and visiting at the Institue of Genetics and Biophysics of the Italian National Research Council in Naples. I am also a Junior Research Fellow for University of Milano Statale ( UNIMI ) in the Laboratory of Elena Cattaneo and my contribution is to set up a pipeline to count the number of repeats in the Huntington’s gene.


Flavia Villani, Research Associate

flavia I am a master’s student at the Institue of Genetics and Biophysics of the Italian National Research Council. I graduated in Biology at the University of Salerno (Italy).

I contributed to a project that studies idiopathic recurrent miscarriage. Currently, I am working to build a library using the Python programming language for the statistical analysis of negative selection using sequence data. In particular, I am focusing on the use of pangenomic sequence data.


Giuliana D’Angelo, Master Student

flavia I am a molecular biology student at University of Naples Federico II currently working on my master’s degree thesis at the Institue of Genetics and Biophysics of the Italian National Research Council.

For my thesis, I am studying embryonic mitochondrial sequences from recurrent miscarriages in humans. In particular, I am doing the variant calling, determining haplogroups, and studying the incidence of deleterious mutations in mitochondrial genes and regulatory regions.


Former members

  • Roberto Sirica, PhD student, 2015-2018

  • Gaia Leandra Cecere, undergraduate student, 2018

  • Marianna Buonaiuto, visiting Postdoc, 2017

  • Lucia De Martino, visiting Graduate Student, 2016





Publications

See them on Google Scholar or in Publication

Peer-reviewed Journals

  1. Anagnostou P, Dominici V, Battaggia C, Lisi A, Sarno S, Boattini A, Calò C, Francalacci P, Vona G, Tofanelli S, Vilar MG, Colonna V, Pagani L, Destro Bisol G. Inter-individual genomic heterogeneity within European population isolates. PLoS One. 2019 Oct 9;14(10):e0214564. doi: 10.1371/journal.pone.0214564. eCollection 2019. PubMed PMID: 31596857

  2. Colonna V, D’Agostino N, Garrison E, Albrechtsen A, Jonas Meisner J, Facchiano A, Cardi T, Tripodi P Genomic diversity and novel genome-wide association with fruit morphology in Capsicum, from 746k polymorphic sites. Sci Rep. 2019 Jul 11;9(1):10067. doi: 10.1038/s41598-019-46136-5. PubMed PMID: 31296904

  3. Petrella V, Aceto S, Colonna V, Saccone G, Sanges R, Polanska N, Volf P, Gradoni L, Bongiorno G, Salvemini M Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera) . BMC Genomics 2019 in press

  4. Sirica R, Buonaiuto M, Petrella V, Sticco L, Tramontano D, Antonini D, Missero C, Guardiola O, Andolfi G, Kumar H, Ayub Q, Xue Y, Tyler-Smith C, Salvemini M, D’Angelo G, Colonna V. Positive selection in Europeans and East-Asians at the ABCA12 gene. Sci Rep. 2019 Mar 19;9(1):4843. doi: 10.1038/s41598-019-40360-9. PubMed PMID: 30890716

  5. Gardner EJ, Lam VK, Harris DN, Chuang NT, Scott EC, Pittard WS, Mills RE; 1000 Genomes Project Consortium, Devine SE. The Mobile Element Locator Tool (MELT): population-scale mobile element discovery and biology. Genome Res. 2017 Nov;27(11):1916-1929. doi: 10.1101/gr.218032.116. Epub 2017 Aug 30. PubMed PMID: 28855259

  6. Xue Y, Mezzavilla M, Haber M, McCarthy S, Chen Y, Narasimhan V, Gilly A, Ayub Q, Colonna V, Southam L, Finan C, Massaia A, Chheda H, Palta P, Ritchie G, Asimit J, Dedoussis G, Gasparini P, Palotie A, Ripatti S, Soranzo N, Toniolo D, Wilson JF, Durbin R, Tyler-Smith C, Zeggini E. Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations. Nat Commun. 2017 Jun 23;8:15927. doi: 10.1038/ncomms15927. PubMed PMID: 28643794

  7. Pagani L, Colonna V, Tyler-Smith C, Ayub Q. An Ethnolinguistic and Genetic Perspective on the Origins of the Dravidian-Speaking Brahui in Pakistan. Man India. 2017;97(1):267-278. PubMed PMID: 28381901

  8. Anagnostou P, Dominici V, Battaggia C, Pagani L, Vilar M, Wells RS, Pettener D, Sarno S, Boattini A, Francalacci P, Colonna V, Vona G, Calò C, Destro Bisol G, Tofanelli S. Overcoming the dichotomy between open and isolated populations using genomic data from a large European dataset. Sci Rep. 2017 Feb 1;7:41614. doi:10.1038/srep41614. PubMed PMID: 28145502

  9. Terreri S, Durso M, Colonna V, Romanelli A, Terracciano D, Ferro M, Perdonà S, Castaldo L, Febbraio F, de Nigris F, Cimmino A. New Cross-Talk Layer between Ultraconserved Non-Coding RNAs, MicroRNAs and Polycomb Protein YY1 in Bladder Cancer. Genes (Basel). 2016 Dec 14;7(12). pii: E127. PubMed PMID: 27983635

  10. Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A. Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome. Hum Mol Genet. 2016 Aug 9. pii: ddw267.PubMed PMID: 27506981

  11. McKerrell T, Moreno T, Ponstingl H, Bolli N, Dias JM, Tischler G, Colonna V, Manasse B, Bench A, Bloxham D, Herman B, Fletcher D, Park N, Quail MA, Manes N, Hodkinson C, Baxter J, Sierra J, Foukaneli T, Warren AJ, Chi J, Costeas P, Rad R, Huntly B, Grove C, Ning Z, Tyler-Smith C, Varela I, Scott M, Nomdedeu J, Mustonen V, Vassiliou GS. Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies. Blood 2016 Apr 27. pii: blood-2015-11-683334. PubMed PMID: 27121471

  12. Olivieri M, Ferro M, Terreri S, Durso M, Romanelli A, Avitabile C, De Cobelli O, Messere A, Bruzzese D, Vannini I, Marinelli L, Novellino E, Zhang W, Incoronato M, Ilardi G, Staibano S, Marra L, Franco R, Perdonà S, Terracciano D, Czerniak B, Liguori GL, Colonna V, Fabbri M, Febbraio F, Calin GA, Cimmino A. Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis. Oncotarget. 2016 Mar 1. PubMed PMID: 26943042

  13. Petrella V, Aceto S, Musacchia F, Colonna V, Robinson M, Benes V, Cicotti G, Bongiorno G, Gradoni L, Volf P, Salvemini M. De novo assembly and sex-specific transcriptome profiling in the sand fly Phlebotomus perniciosus (Diptera, Phlebotominae), a major Old World vector of Leishmania infantum. BMC Genomics. 2015 Oct 23;16(1):847. PubMed PMID: 26493315

  14. 1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA, Abecasis GR. A global reference for human genetic variation. Nature. 2015 Oct 1;526(7571):68-74. PubMed PMID: 26432245

  15. Shah SS, Mohyuddin A, Colonna V, Mehdi SQ, Ayub Q. Monoamine Oxidase A gene polymorphisms and self reported aggressive behaviour in a Pakistani ethnic group. J Pak Med Assoc. 2015 Aug;65(8):818-24. PubMed PMID: 26228323

  16. Delaneau O, Marchini J; 1000 Genomes Project Consortium; 1000 Genomes Project Consortium. Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nat Commun. 2014 Jun 13;5:3934. doi: 10.1038/ncomms4934. PubMed PMID: 25653097

  17. Mezzavilla M, Vozzi D, Pirastu N, Girotto G, d’Adamo P, Gasparini P, Colonna V. Genetic landscape of populations along the Silk Road: admixture and migration patterns. BMC Genet. 2014 Dec 5;15:131. PubMed PMID: 25476266

  18. Panoutsopoulou K, Hatzikotoulas K, Xifara DK, Colonna V, Farmaki AE, Ritchie GR, Southam L, Gilly A, Tachmazidou I, Fatumo S, Matchan A, Rayner NW, Ntalla I, Mezzavilla M, Chen Y, Kiagiadaki C, Zengini E, Mamakou V, Athanasiadis A, Giannakopoulou M, Kariakli VE, Nsubuga RN, Karabarinde A, Sandhu M, McVean G, Tyler-Smith C, Tsafantakis E, Karaleftheri M, Xue Y, Dedoussis G, Zeggini E. Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants. Nat Commun. 2014 Nov 6;5:5345. doi: 10.1038/ncomms6345. PubMed PMID: 25373335

  19. Colonna V, Ayub Q, Chen Y, Pagani L, Luisi P, Pybus M, Garrison E, Xue Y, Tyler-Smith C; 1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences. Genome Biol. 2014 Jun 30;15(6):R88. doi: 10.1186/gb-2014-15-6-r88. PubMed PMID: 24980144

  20. Ayub Q, Moutsianas L, Chen Y, Panoutsopoulou K, Colonna V, Pagani L, Prokopenko I, Ritchie GR, Tyler-Smith C, McCarthy MI, Zeggini E, Xue Y. Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes. Am J Hum Genet. 2014 Feb 6;94(2):176-85. doi: 10.1016/j.ajhg.2013.12.010. Epub 2014 Jan 9. PubMed PMID: 24412096

  21. Sikora MJ, Colonna V, Xue Y, Tyler-Smith C. Modeling the contrasting Neolithic male lineage expansions in Europe and Africa. Investig Genet. 2013 Nov 21;4(1):25. doi: 10.1186/2041-2223-4-25. PubMed PMID: 24262073

  22. Khurana E*, Fu Y*, Colonna V*, Mu XJ*, Kang HM, Lappalainen T, Sboner A, Lochovsky L, Chen J, Harmanci A, Das J, Abyzov A, Balasubramanian S, Beal K, Chakravarty D, Challis D, Chen Y, Clarke D, Clarke L, Cunningham F, Evani US, Flicek P, Fragoza R, Garrison E, Gibbs R, Gümüs ZH, Herrero J, Kitabayashi N, Kong Y, Lage K, Liluashvili V, Lipkin SM, MacArthur DG, Marth G, Muzny D, Pers TH, Ritchie GR, Rosenfeld JA, Sisu C, Wei X, Wilson M, Xue Y, Yu F; 1000 Genomes Project Consortium, Dermitzakis ET, Yu H, Rubin MA, Tyler-Smith C, Gerstein M. Integrative annotation of variants from 1092 humans: application to cancer genomics. Science. 2013 Oct 4;342(6154):1235587. doi: 10.1126/science.1235587. PubMed PMID: 24092746 *equal contribution

  23. Ghirotto S, Tassi F, Fumagalli E, Colonna V, Sandionigi A, Lari M, Vai S, Petiti E, Corti G, Rizzi E, De Bellis G, Caramelli D, Barbujani G. Origins and evolution of the Etruscans' mtDNA. PLoS One. 2013;8(2):e55519. PubMed PMID: 23405165

  24. 1000 Genomes Project Consortium, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012 Nov 1;491(7422):56-65. PubMed PMID: 23128226

  25. Boraska V, Jerončić A, Colonna V, Southam L, Nyholt DR, Rayner NW, Perry JR, Toniolo D, Albrecht E, Ang W, Bandinelli S, Barbalic M, Barroso I, Beckmann JS, Biffar R, Boomsma D, Campbell H, Corre T, Erdmann J, Esko T, Fischer K, Franceschini N, Frayling TM, Girotto G, Gonzalez JR, Harris TB, Heath AC, Heid IM, Hoffmann W, Hofman A, Horikoshi M, Zhao JH, Jackson AU, Hottenga JJ, Jula A, Kähönen M, Khaw KT, Kiemeney LA, Klopp N, Kutalik Z, Lagou V, Launer LJ, Lehtimäki T, Lemire M, Lokki ML, Loley C, Luan J, Mangino M, Mateo Leach I, Medland SE, Mihailov E, Montgomery GW, Navis G, Newnham J, Nieminen MS, Palotie A, Panoutsopoulou K, Peters A, Pirastu N, Polasek O, Rehnström K, Ripatti S, Ritchie GR, Rivadeneira F, Robino A, Samani NJ, Shin SY, Sinisalo J, Smit JH, Soranzo N, Stolk L, Swinkels DW, Tanaka T, Teumer A, Tönjes A, Traglia M, Tuomilehto J, Valsesia A, van Gilst WH, van Meurs JB, Smith AV, Viikari J, Vink JM, Waeber G, Warrington NM, Widen E, Willemsen G, Wright AF, Zanke BW, Zgaga L; Wellcome Trust Case Control Consortium, Boehnke M, d’Adamo AP, de Geus E, Demerath EW, den Heijer M, Eriksson JG, Ferrucci L, Gieger C, Gudnason V, Hayward C, Hengstenberg C, Hudson TJ, Järvelin MR, Kogevinas M, Loos RJ, Martin NG, Metspalu A, Pennell CE, Penninx BW, Perola M, Raitakari O, Salomaa V, Schreiber S, Schunkert H, Spector TD, Stumvoll M, Uitterlinden AG, Ulivi S, van der Harst P, Vollenweider P, Völzke H, Wareham NJ, Wichmann HE, Wilson JF, Rudan I, Xue Y, Zeggini E. Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet. 2012 Nov 1;21(21):4805-15. PubMed PMID: 22843499

  26. Colonna V, Pistis G, Bomba L, Mona S, Matullo G, Boano R, Sala C, Viganò F, Torroni A, Achilli A, Hooshiar Kashani B, Malerba G, Gambaro G, Soranzo N, Toniolo D. Small effective population size and genetic homogeneity in the Val Borbera isolate. Eur J Hum Genet. 2013 Jan;21(1):89-94. PubMed PMID: 22713810

  27. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012 Mar 25;484(7395):519-23. PubMed PMID: 22446628

  28. Colonna V, Pagani L, Xue Y, Tyler-Smith C. A world in a grain of sand: human history from genetic data. Genome Biol. 2011 Nov 21;12(11):234. PubMed PMID: 22104725

  29. Kutanan W, Kampuansai J, Colonna V, Nakbunlung S, Lertvicha P, Seielstad M, Bertorelle G, Kangwanpong D. Genetic affinity and admixture of northern Thai people along their migration route in northern Thailand: evidence from autosomal STR loci. J Hum Genet. 2011 Feb;56(2):130-7. PubMed PMID: 21107341

  30. Colonna V, Boattini A, Guardiano C, Dall’ara I, Pettener D, Longobardi G, Barbujani G. Long-range comparison between genes and languages based on syntactic distances. Hum Hered. 2010;70(4):245-54. PubMed PMID: 20948220

  31. Barbujani G, Colonna V. Human genome diversity: frequently asked questions. Trends Genet. 2010 Jul;26(7):285-95. PubMed PMID: 20471132

  32. Bronberg RA, Dipierri JE, Alfaro EL, Barrai I, Rodríguez-Larralde A, Castilla EE, Colonna V, Rodríguez-Arroyo G, Bailliet G. Isonymy structure of Buenos Aires city. Hum Biol. 2009 Aug;81(4):447-61. PubMed PMID: 20067369

  33. Colonna V, Nutile T, Ferrucci RR, Fardella G, Aversano M, Barbujani G, Ciullo M. Comparing population structure as inferred from genealogical versus genetic information. Eur J Hum Genet. 2009 Dec;17(12):1635-41.PubMed PMID: 19550436

  34. Belle EM, Benazzo A, Ghirotto S, Colonna V, Barbujani G. Comparing models on the genealogical relationships among Neandertal, Cro-Magnoid and modern Europeans by serial coalescent simulations. Heredity (Edinb). 2009 Mar;102(3):218-25. PubMed PMID: 18971954

  35. Ciullo M, Nutile T, Dalmasso C, Sorice R, Bellenguez C, Colonna V, Persico MG, Bourgain C. Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento. Diabetes. 2008 Mar;57(3):783-90. PubMed PMID:

  36. Colonna V, Nutile T, Astore M, Guardiola O, Antoniol G, Ciullo M, Persico MG. Campora: a young genetic isolate in South Italy. Hum Hered. 2007;64(2):123-35. PubMed PMID: 17476112

  37. Ciullo M, Bellenguez C, Colonna V, Nutile T, Calabria A, Pacente R, Iovino G, Trimarco B, Bourgain C, Persico MG. New susceptibility locus for hypertension on chromosome 8q by efficient pedigree-breaking in an Italian isolate. Hum Mol Genet. 2006 May 15;15(10):1735-43. PubMed PMID: 16611673

  38. Tarsitano M, De Falco S, Colonna V, McGhee JD, Persico MG. The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis. FASEB J. 2006 Feb;20(2):227-33. PubMed PMID: 16449794

Book chapters

  • 2011 Barbujani G., Colonna V. (2011). Genetic bases of human biodiversity: an update. . In: Zachos F.E., Habel J.C. . Biodiversity Hotspots . p. 97-120, berlino:springer, ISBN: 9783642209918

  • 2010 BARBUJANI G, COLONNA V (2010). Genetic bases of human biodiversity: an update. In: ZACHOS F. BIODIVERSITY HOTSPOTS. BERLIN:Springer

Past Research

At this link is possible to found our past Research



Contacts

Vincenza Colonna, PhD

Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso" piano R, stanza 11 via Pietro Castellino 111 - 80131 Napoli - Italy - map

tel. +39 081 6132 254